Organochlorine insecticides

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The text on this page is taken from an equivalent page of the IEHIAS-project.
  • The use of organochlorine insecticides was discontinued after the 1960s due to their persistent contamination.
  • However, they can still be detected in biological samples.
  • Nine organochlorines (aldrin, chlordane, DDT, dieldrin, endrin, heptachlor, hexachlorobenzene, mirex and toxaphene) are subject of the Stockholm Convention on POPs

Organochlorine insecticides as biomarkers

Sample collection and storage

Matrix:

  • Biological monitoring can be carried out in blood, fatty tissue and urine

Kinetics:

  • Uptake through inhalation, dermal uptake or ingestion
  • Detoxification through induction of cytochrome P450 activates organochlorines to genotoxic species

Sampling conditions:

  • Standard sampling procedures should be taken into account
  • Since a significant number of compounds may be present in the general “unexposed” population, pre-exposure sampling is recommended for comparison with post-exposure levels

Sample measurement

Analytical aspects:

  • Serum or plasma is extracted using liquid or solid-phase extraction and analyzed using GC and ECD or MS
  • Comparable methods are used for other lipid rich matrices such as adipose tissue or breast milk
  • Metabolites in urine can be detected in the ng/l level in urine using SPE and GC-MS-MS

Performance characteristics:

No data available

Validation:

No data available

Confounding factors:

No data available

Data interpretation

Concentrations reported in literature:

No data available

Dose-response/effect relationships:

  • Organochlorine insecticides are linked with STS, non-Hodgkin’s lymphoma, leukemia and, less consistently, with lung and breast cancers.
  • They may also affect fertility mechanisms at relatively low levels (0.41 ng/ml)

Time trend, geographical variation, susceptibel groups:

No data available

See also

Integrated Environmental Health Impact Assessment System
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