IRIS/Inhalation unit risks

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Question

What are the Inhalation unit risks according to the IRIS database?

Answer

Inhalation unit risks

IRIS/Inhalation unit risks(per µg /m
ObsSubstanceCASRNPrecursor Effect/ Tumor TypeExtrapolation MethodUnitInhalation unit risksStudy RouteIRIS identifier
1Acenaphthene83-32-9Not Assessed under the IRIS program.
2Acenaphthylene208-96-8Not Assessed under the IRIS program.
3Acephate30560-19-1Not Assessed under the IRIS program.
4Acetaldehyde75-07-0Nasal squamous cell carcinoma or adenocarcinomaLinearized multistage-variable exposure input form (extra risk) per µg/m32.2x10-6Inhalation
5Acetochlor34256-82-1Not Assessed under the IRIS program.
6Acetone67-64-1Not Assessed under the IRIS program.
7Acetonitrile75-05-8Not Assessed under the IRIS program.
8Acetophenone98-86-2Not Assessed under the IRIS program.
9Acetyl chloride75-36-5Not Assessed under the IRIS program.
10Acifluorfen, sodium62476-59-9Not Assessed under the IRIS program.
11Acrolein107-02-8Not Assessed under the IRIS program.
12Acrylamide79-06-1thyroid tumors and tunica vaginalis mesotheliomasMultistage model with linear extrapolation from the point of departure (BMDL), summed risk.per µg /m31x10-4Oral, drinking water
13Acrylic acid79-10-7Not Assessed under the IRIS program.
14Acrylonitrile107-13-1Respiratory cancerAverage relative riskper µg /m36.8x10-5Inhalation
15Adiponitrile111-69-3Not Assessed under the IRIS program.
16Alachlor15972-60-8Not Assessed under the IRIS program.
17Alar1596-84-5Not Assessed under the IRIS program.
18Aldicarb116-06-3Not Assessed under the IRIS program.
19Aldicarb sulfone1646-88-4Not Assessed under the IRIS program.
20Aldrin309-00-2Liver carcinomaLinearized multistage procedure, extra riskper µg /m34.9x10-3Oral, Diet
21Ally74223-64-6Not Assessed under the IRIS program.
22Allyl alcohol107-18-6Not Assessed under the IRIS program.
23Allyl chloride107-05-1Not Assessed under the IRIS program.
24Aluminum phosphide20859-73-8Not Assessed under the IRIS program.
25Amdro67485-29-4Not Assessed under the IRIS program.
26Ametryn834-12-8Not Assessed under the IRIS program.
274-Aminopyridine504-24-5Not Assessed under the IRIS program.
28Amitraz33089-61-1Not Assessed under the IRIS program.
29Ammonia7664-41-7Not Assessed under the IRIS program.
30Ammonium acetate631-61-8Not Assessed under the IRIS program.
31Ammonium methacrylate16325-47-6Not Assessed under the IRIS program.
32Ammonium sulfamate7773-06-0Not Assessed under the IRIS program.
33Aniline62-53-3Not Assessed under the IRIS program.
34ortho-Anisidine90-04-0Not Assessed under the IRIS program.
35Anthracene120-12-7Not Assessed under the IRIS program.
36Antimony7440-36-0Not Assessed under the IRIS program.
37Antimony trioxide1309-64-4Not Assessed under the IRIS program.
38Apollo74115-24-5Not Assessed under the IRIS program.
39Aramite140-57-8Neoplastic liver nodules and carcinomasLinearized multistage procedure, extra riskper µg/m37.1x10-6Oral, Diet
40Aroclor 101612674-11-2Not Assessed under the IRIS program.
41Aroclor 124812672-29-6Not Assessed under the IRIS program.
42Aroclor 125411097-69-1Not Assessed under the IRIS program.
43Arsenic, inorganic7440-38-2Lung cancerAbsolute-risk linear modelper µg/m34.3x10-3Inhalation, Occupational exposure
44Arsine7784-42-1Not Assessed under the IRIS program.
45Asbestos1332-21-4Lung cancer and mesotheliomaAdditive risk of lung cancer and mesothelioma, using relative risk model for lung cancer and absolute risk model for mesotheliomaper f/mL2.3x10-1Inhalation, Occupational exposure
46Assure76578-14-8Not Assessed under the IRIS program.
47Asulam3337-71-1Not Assessed under the IRIS program.
48Atrazine1912-24-9Not Assessed under the IRIS program.
49Avermectin B165195-55-3Not Assessed under the IRIS program.
50Azobenzene103-33-3Abdominal cavity sarcomasLinearized multistage procedure, extra riskper µg /m33.1x10-5Oral, Diet
51Barium and Compounds7440-39-3Not Assessed under the IRIS program.
52Barium cyanide542-62-1Not Assessed under the IRIS program.
53Baygon114-26-1Not Assessed under the IRIS program.
54Bayleton43121-43-3Not Assessed under the IRIS program.
55Baythroid68359-37-5Not Assessed under the IRIS program.
56Benefin1861-40-1Not Assessed under the IRIS program.
57Benomyl17804-35-2Not Assessed under the IRIS program.
58Bentazon (Basagran)25057-89-0Not Assessed under the IRIS program.
59Benz[a]anthracene56-55-3Not Assessed under the IRIS program.
60Benzaldehyde100-52-7Not Assessed under the IRIS program.
61Benzene71-43-2LeukemiaLow-dose linearity utilizing maximum likelihood estimatesper µg /m32.2x10-6Inhalation
62Benzene71-43-2LeukemiaLow-dose linearity utilizing maximum likelihood estimatesper µg /m37.8x10-6Inhalation
63Benzidine92-87-5Bladder tumorsOne-hit with time factor, extra riskper µg /m36.7x10-2Inhalation, Occupational exposure
64Benzo[a]pyrene (BaP)50-32-8Not Assessed under the IRIS program.
65Benzo[b]fluoranthene205-99-2Not Assessed under the IRIS program.
66Benzo[g,h,i]perylene191-24-2Not Assessed under the IRIS program.
67Benzo[k]fluoranthene207-08-9Not Assessed under the IRIS program.
68Benzoic acid65-85-0Not Assessed under the IRIS program.
69Benzotrichloride98-07-7Not Assessed under the IRIS program.
70Benzyl chloride100-44-7Not Assessed under the IRIS program.
71Beryllium and compounds7440-41-7Lung cancerRelative riskper µg /m32.4x10-3Inhalation, Occupational exposure
72Bidrin141-66-2Not Assessed under the IRIS program.
73Biphenthrin82657-04-3Not Assessed under the IRIS program.
741,1-Biphenyl92-52-4Not Assessed under the IRIS program.
75Bis(2-chloro-1-methylethyl) ether108-60-1Not Assessed under the IRIS program.
76Bis(2-chloroethoxy)methane111-91-1Not Assessed under the IRIS program.
77Bis(chloroethyl)ether (BCEE)111-44-4HepatomasLinearized multistage procedure, extra riskper µg /m33.3x10-4Oral, Gavage followed by diet
78Bis(chloromethyl)ether (BCME)542-88-1Respiratory tract tumorsLinearized multistage procedure, extra riskper µg /m36.2x10-2Inhalation
79Bisphenol A.80-05-7Not Assessed under the IRIS program.
80Boron and Compounds7440-42-8Not Assessed under the IRIS program.
81Bromate15541-45-4Information reviewed but value not estimated. Refer to IRIS Summary.
82Brominated dibenzofuransNANot Assessed under the IRIS program.
83Bromobenzene108-86-1Not Assessed under the IRIS program.
84Bromochloromethane74-97-5Not Assessed under the IRIS program.
85Bromodichloromethane75-27-4Not Assessed under the IRIS program.
86p-Bromodiphenyl ether101-55-3Not Assessed under the IRIS program.
87Bromoform75-25-2Neoplastic lesions in the large intestineLinearized multistage procedure, extra riskper µg /m31.1x10-6Oral, Gavage in corn oil
88Bromomethane74-83-9Not Assessed under the IRIS program.
89Bromotrichloromethane75-62-7Not Assessed under the IRIS program.
90Bromoxynil1689-84-5Not Assessed under the IRIS program.
91Bromoxynil octanoate1689-99-2Not Assessed under the IRIS program.
921,3-Butadiene106-99-0LeukemiaLinear extrapolation from LEC01 (0.254 ppm); LEC01 derived from linear relative rate model (RR = 1 + (B)(x)) using lifetable analysis with leukemia incidence data; an adjustment factor of 2 was applied.per µg /m33x10-5Inhalation
93n-Butanol71-36-3Not Assessed under the IRIS program.
94Butyl benzyl phthalate85-68-7Not Assessed under the IRIS program.
95Butylate2008-41-5Not Assessed under the IRIS program.
96t-Butylchloride507-20-0Not Assessed under the IRIS program.
97Butylphthalyl butylglycolate (BPBG)85-70-1Not Assessed under the IRIS program.
98Cacodylic acid75-60-5Not Assessed under the IRIS program.
99Cadmium7440-43-9Lung, trachea, bronchus cancer deathsTwo stage; only first affected by exposure; extra riskper µg /m31.8x10-3Inhalation, Exposure in the workplace
100Calcium cyanide592-01-8Not Assessed under the IRIS program.
101Caprolactam105-60-2Not Assessed under the IRIS program.
102Captafol2425-06-1Not Assessed under the IRIS program.
103Captan133-06-2Not Assessed under the IRIS program.
104Carbaryl63-25-2Not Assessed under the IRIS program.
105Carbofuran1563-66-2Not Assessed under the IRIS program.
106Carbon disulfide75-15-0Not Assessed under the IRIS program.
107Carbon tetrachloride56-23-5PheochromocytomaLog-probit model with linear extrapolation from the POD (LEC10).per µg /m36x10-6Inhalation
108Carbonyl sulfide463-58-1Not Assessed under the IRIS program.
109Carbosulfan55285-14-8Not Assessed under the IRIS program.
110Carboxin5234-68-4Not Assessed under the IRIS program.
111Cerium Oxide and Cerium Compounds1306-38-3Not Assessed under the IRIS program.
112Chloral hydrate302-17-0Not Assessed under the IRIS program.
113Chloramben133-90-4Not Assessed under the IRIS program.
114Chlordane (Technical)12789-03-6Hepatocellular carcinomaLinearized multistage procedure, extra riskper µg /m31x10-4<7sup>Oral, Diet
115Chlordecone (Kepone)143-50-0Information reviewed but value not estimated. Refer to IRIS Summary.
116Chlorimuron-ethyl90982-32-4Not Assessed under the IRIS program.
117Chlorine7782-50-5Not Assessed under the IRIS program.
118Chlorine cyanide506-77-4Not Assessed under the IRIS program.
119Chlorine dioxide10049-04-4Not Assessed under the IRIS program.
120Chlorite (sodium salt)7758-19-2Not Assessed under the IRIS program.
1211-Chloro-1,1-difluoroethane75-68-3Not Assessed under the IRIS program.
1222-Chloroacetophenone532-27-4Not Assessed under the IRIS program.
123p-Chloroaniline106-47-8Not Assessed under the IRIS program.
124Chlorobenzene108-90-7Not Assessed under the IRIS program.
125Chlorobenzilate510-15-6Not Assessed under the IRIS program.
1261-Chlorobutane109-69-3Not Assessed under the IRIS program.
1272-Chlorobutane78-86-4Not Assessed under the IRIS program.
128Chlorocyclopentadiene41851-50-7Not Assessed under the IRIS program.
129Chlorodifluoromethane75-45-6Not Assessed under the IRIS program.
130Chloroform67-66-3Hepatocellular carcinomaLinearized multistage procedure, extra riskper µg /m32.3x10-5Oral, Gavage
131Chloromethyl methyl ether (CMME)107-30-2Not Assessed under the IRIS program.
132beta-Chloronaphthalene91-58-7Not Assessed under the IRIS program.
1332-Chlorophenol95-57-8Not Assessed under the IRIS program.
134p-Chlorophenyl methyl sulfide123-09-1Not Assessed under the IRIS program.
135p-Chlorophenyl methyl sulfone98-57-7Not Assessed under the IRIS program.
136p-Chlorophenyl methyl sulfoxide934-73-6Not Assessed under the IRIS program.
137Chloroprene126-99-8alveolar/ bronchiolar adenoma or carcinoma; hemangioma/ hemangiosarcoma (all organs); mammary gland adenocarcinoma, carcinoma, or adenoacanthoma; forestomach squamous cell papilloma or carcinoma; hepatocellular adenoma or carcinoma; Harderian gland adenoma or carcinoma; skin sarcoma; and Zymbal's gland carcinomaMultistage model with linear extrapolation from the point of departure (BMDL), summed risk.per µg /m33x10-4Inhalation
138Chlorothalonil1897-45-6Not Assessed under the IRIS program.
139o-Chlorotoluene95-49-8Not Assessed under the IRIS program.
140Chlorpropham101-21-3Not Assessed under the IRIS program.
141Chlorpyrifos2921-88-2Not Assessed under the IRIS program.
142Chlorsulfuron64902-72-3Not Assessed under the IRIS program.
143Chromium(III), insoluble salts16065-83-1Not Assessed under the IRIS program.
144Chromium(VI)18540-29-9Lung cancerMultistage, extra riskper µg /m31.2x10-2Inhalation, Occupational exposure
145Chrysene218-01-9Not Assessed under the IRIS program.
146Coke oven emissions8007-45-2Respiratory cancerLinearized multistage procedureper µg /m36.2x10-4Inhalation, Occupational
147Copper7440-50-8Not Assessed under the IRIS program.
148Copper cyanide544-92-3Not Assessed under the IRIS program.
149Creosote8001-58-9Not Assessed under the IRIS program.
150Crotonaldehyde123-73-9Not Assessed under the IRIS program.
151Cumene98-82-8Not Assessed under the IRIS program.
152Cyanazine21725-46-2Not Assessed under the IRIS program.
153Cyanide, free57-12-5Not Assessed under the IRIS program.
154Cyanogen460-19-5Not Assessed under the IRIS program.
155Cyanogen bromide506-68-3Not Assessed under the IRIS program.
156Cyclohexane110-82-7Not Assessed under the IRIS program.
157Cyclohexanone108-94-1Not Assessed under the IRIS program.
158Cyclohexylamine108-91-8Not Assessed under the IRIS program.
159Cyhalothrin/Karate68085-85-8Not Assessed under the IRIS program.
160Cypermethrin52315-07-8Not Assessed under the IRIS program.
161Cyromazine66215-27-8Not Assessed under the IRIS program.
162Dacthal1861-32-1Not Assessed under the IRIS program.
163Dalapon, sodium salt75-99-0Not Assessed under the IRIS program.
164Danitol39515-41-8Not Assessed under the IRIS program.
1652,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209)1163-19-5Not Assessed under the IRIS program.
166Demeton8065-48-3Not Assessed under the IRIS program.
167Di (2-ethylhexyl)phthalate (DEHP)117-81-7Not Assessed under the IRIS program.
168Di(2-ethylhexyl)adipate103-23-1Not Assessed under the IRIS program.
1692,4-Diaminotoluene95-80-7Not Assessed under the IRIS program.
170Diazomethane334-88-3Not Assessed under the IRIS program.
171Dibenz[a,h]anthracene53-70-3Not Assessed under the IRIS program.
172Dibenzofuran132-64-9Not Assessed under the IRIS program.
1731,2-Dibromo-3-chloropropane (DBCP)96-12-8Not Assessed under the IRIS program.
1741,4-Dibromobenzene106-37-6Not Assessed under the IRIS program.
175Dibromochloromethane124-48-1Not Assessed under the IRIS program.
176Dibromodichloromethane594-18-3Not Assessed under the IRIS program.
177p,p'-Dibromodiphenyl ether2050-47-7Not Assessed under the IRIS program.
1781,2-Dibromoethane106-93-4Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomasMultistage-Weibull model; linear extrapolation from lower 95% confidence limit on dose associated with extra risk (adjusted for background) at point of departure at lower end of data range.per µg /m36x10-4Inhalation
1791,2-Dibromoethane106-93-4Nasal cavity (includes adenoma, adenocarcinoma, papillary adenoma, squamous cell carcinoma, and or/papilloma), hemangiosarcomas, mesotheliomasMultistage-Weibull model; linear extrapolation from lower 95% confidence limit on dose associated with extra risk (adjusted for background) at point of departure at lower end of data range.per µg /m33x10-4Inhalation
180Dibutyl phthalate84-74-2Not Assessed under the IRIS program.
181Dicamba1918-00-9Not Assessed under the IRIS program.
182Dichloroacetic acid79-43-6Information reviewed but value not estimated. Refer to IRIS Summary.
1831,3-Dichlorobenzene541-73-1Not Assessed under the IRIS program.
1841,4-Dichlorobenzene106-46-7Not Assessed under the IRIS program.
1851,2-Dichlorobenzene95-50-1Not Assessed under the IRIS program.
1863,3'-Dichlorobenzidine91-94-1Not Assessed under the IRIS program.
187Dichlorodifluoromethane75-71-8Not Assessed under the IRIS program.
188p,p'-Dichlorodiphenyl dichloroethane (DDD)72-54-8Not Assessed under the IRIS program.
189p,p'-Dichlorodiphenyldichloroethylene (DDE)72-55-9Not Assessed under the IRIS program.
190p,p'-Dichlorodiphenyltrichloroethane (DDT)50-29-3Liver tumors, benign and malignantLinear multistage procedure, extra riskper µg /m39.7x10-5Oral,Diet
1911,2-Dichloroethane107-06-2HemangiosarcomasLinearized multistage procedure, extra riskper µg /m32.6x10-5Oral,Gavage
1921,1-Dichloroethane75-34-3Not Assessed under the IRIS program.
193trans-1,2-Dichloroethylene156-60-5Not Assessed under the IRIS program.
194cis-1,2-Dichloroethylene156-59-2Not Assessed under the IRIS program.
1951,1-Dichloroethylene (1,1-DCE)75-35-4Information reviewed but value not estimated. Refer to IRIS Summary.
196Dichloromethane75-09-2Hepatocellular carcinomas or adenomas, bronchoalveolar carcinomas or adenomasMultistage model with linear extrapolation from the point of departure (BMDL10)per µg /m31x10-8Inhalation
1972,4-Dichlorophenol120-83-2Not Assessed under the IRIS program.
1984-(2,4-Dichlorophenoxy)butyric acid (2,4-DB)94-82-6Not Assessed under the IRIS program.
1992,4-Dichlorophenoxyacetic acid (2,4-D)94-75-7Not Assessed under the IRIS program.
2001,2-Dichloropropane78-87-5Not Assessed under the IRIS program.
2012,3-Dichloropropanol616-23-9Not Assessed under the IRIS program.
2021,3-Dichloropropene542-75-6Bronchioalveolar adenomaLinearized multistage model, extra riskper µg /m34x10-6Inhalation
203Dichlorvos62-73-7Not Assessed under the IRIS program.
204Dicofol115-32-2Not Assessed under the IRIS program.
205Dieldrin60-57-1Liver carcinomaLinearized multistage procedure, extra riskper µg /m34.6x10-3Oral, Diet
206Diesel engine exhaustNAInformation reviewed but value not estimated. Refer to IRIS Summary.
207Diethyl phthalate84-66-2Not Assessed under the IRIS program.
208Diethyl sulfate64-67-5Not Assessed under the IRIS program.
209Diethyl-p-nitrophenylphosphate311-45-5Not Assessed under the IRIS program.
210Diethylene glycol dinitrate (DEGDN)693-21-0Not Assessed under the IRIS program.
211Difenzoquat43222-48-6Not Assessed under the IRIS program.
212Diflubenzuron35367-38-5Not Assessed under the IRIS program.
2131,1-Difluoroethane75-37-6Not Assessed under the IRIS program.
214Diisopropyl methylphosphonate (DIMP)1445-75-6Not Assessed under the IRIS program.
215Dimethipin55290-64-7Not Assessed under the IRIS program.
216Dimethoate60-51-5Not Assessed under the IRIS program.
217Dimethyl phthalate131-11-3Not Assessed under the IRIS program.
218Dimethyl sulfate77-78-1Not Assessed under the IRIS program.
219Dimethyl terephthalate (DMT)120-61-6Not Assessed under the IRIS program.
220Dimethylamine124-40-3Not Assessed under the IRIS program.
221N-N-Dimethylaniline121-69-7Not Assessed under the IRIS program.
2223,3-Dimethylbenzidine119-93-7Not Assessed under the IRIS program.
223N,N-Dimethylformamide68-12-2Not Assessed under the IRIS program.
2243,4-Dimethylphenol95-65-8Not Assessed under the IRIS program.
2252,6-Dimethylphenol576-26-1Not Assessed under the IRIS program.
2262,4-Dimethylphenol105-67-9Not Assessed under the IRIS program.
2274,6-Dinitro-o-cyclohexyl phenol131-89-5Not Assessed under the IRIS program.
228m-Dinitrobenzene99-65-0Not Assessed under the IRIS program.
229o-Dinitrobenzene528-29-0Not Assessed under the IRIS program.
2302,4-Dinitrophenol51-28-5Not Assessed under the IRIS program.
2312,4-Dinitrotoluene121-14-2Not Assessed under the IRIS program.
2322,4-/2,6-Dinitrotoluene mixtureNANot Assessed under the IRIS program.
233Dinoseb88-85-7Not Assessed under the IRIS program.
2341,4-Dioxane123-91-1Information reviewed but value not estimated. Refer to IRIS Summary.
235Diphenamid957-51-7Not Assessed under the IRIS program.
236Diphenylamine122-39-4Not Assessed under the IRIS program.
2371,2-Diphenylhydrazine122-66-7Hepatocellular carcinomas and neoplastic liver nodulesLinearized multistage procedure, extra riskper µg /m32.2x10-4Oral, Diet
238Diquat85-00-7Not Assessed under the IRIS program.
239Disulfoton298-04-4Not Assessed under the IRIS program.
2401,4-Dithiane505-29-3Not Assessed under the IRIS program.
241Diuron330-54-1Not Assessed under the IRIS program.
242Dodine2439-10-3Not Assessed under the IRIS program.
243Endosulfan115-29-7Not Assessed under the IRIS program.
244Endothall145-73-3Not Assessed under the IRIS program.
245Endrin72-20-8Not Assessed under the IRIS program.
246Epichlorohydrin106-89-8Nasal cavity tumorsLinearized multistage procedure, extra riskper µg /m31.2x10-6Inhalation
2471,2-Epoxybutane (EBU)106-88-7Not Assessed under the IRIS program.
248Ethephon16672-87-0Not Assessed under the IRIS program.
249Ethion563-12-2Not Assessed under the IRIS program.
2502-Ethoxyethanol110-80-5Not Assessed under the IRIS program.
251Ethyl acetate141-78-6Not Assessed under the IRIS program.
252Ethyl carbamate51-79-6Not Assessed under the IRIS program.
253Ethyl chloride75-00-3Not Assessed under the IRIS program.
254S-Ethyl dipropylthiocarbamate (EPTC)759-94-4Not Assessed under the IRIS program.
255Ethyl ether60-29-7Not Assessed under the IRIS program.
256Ethyl p-nitrophenyl phenylphosphorothioate (EPN)2104-64-5Not Assessed under the IRIS program.
257Ethylbenzene100-41-4Not Assessed under the IRIS program.
258Ethylene diamine107-15-3Not Assessed under the IRIS program.
259Ethylene glycol107-21-1Not Assessed under the IRIS program.
260Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)111-76-2Information reviewed but value not estimated. Refer to IRIS Summary.
261Ethylene thiourea (ETU)96-45-7Not Assessed under the IRIS program.
262Ethyleneimine151-56-4Not Assessed under the IRIS program.
263Ethylphthalyl ethylglycolate (EPEG)84-72-0Not Assessed under the IRIS program.
264Express101200-48-0Not Assessed under the IRIS program.
265Fenamiphos22224-92-6Not Assessed under the IRIS program.
266Fluometuron2164-17-2Not Assessed under the IRIS program.
267Fluoranthene206-44-0Not Assessed under the IRIS program.
268Fluorene86-73-7Not Assessed under the IRIS program.
269Fluorine (soluble fluoride)7782-41-4Not Assessed under the IRIS program.
270Fluridone59756-60-4Not Assessed under the IRIS program.
271Flurprimidol56425-91-3Not Assessed under the IRIS program.
272Flutolanil66332-96-5Not Assessed under the IRIS program.
273Fluvalinate69409-94-5Not Assessed under the IRIS program.
274Folpet133-07-3Not Assessed under the IRIS program.
275Fomesafen72178-02-0Not Assessed under the IRIS program.
276Fonofos944-22-9Not Assessed under the IRIS program.
277Formaldehyde50-00-0Squamous cell carcinomaLinearized multistage procedure, additional riskper µg /m31.3x10-5Inhalation
278Formic acid64-18-6Not Assessed under the IRIS program.
279Fosetyl-al39148-24-8Not Assessed under the IRIS program.
280Furan110-00-9Not Assessed under the IRIS program.
281Furfural98-01-1Not Assessed under the IRIS program.
282Furmecyclox60568-05-0Not Assessed under the IRIS program.
283Glufosinate-ammonium77182-82-2Not Assessed under the IRIS program.
284Glycidaldehyde765-34-4Not Assessed under the IRIS program.
285Glyphosate1071-83-6Not Assessed under the IRIS program.
286Haloxyfop-methyl69806-40-2Not Assessed under the IRIS program.
287Harmony79277-27-3Not Assessed under the IRIS program.
288Heptachlor76-44-8Hepatocellular carcinomasLinearized multistage procedure, extra risk per µg/m31.3x10-3Oral, Diet
289Heptachlor epoxide1024-57-3Hepatocellular carcinomasLinearized multistage procedure, extra riskper µg/m32.6x10-3Oral, Diet
290n-Heptane142-82-5Not Assessed under the IRIS program.
291Hexabromobenzene87-82-1Not Assessed under the IRIS program.
292Hexabromodiphenyl ether36483-60-0Not Assessed under the IRIS program.
2932,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153)68631-49-2Not Assessed under the IRIS program.
294Hexachlorobenzene118-74-1Hepatocellular carcinomaLinearized multistage, extra riskper µg /m34.6x10-4Oral, Diet
295Hexachlorobutadiene87-68-3Renal tubular adenomas and adenocarcinomasLinearized multistage procedure, extra riskper µg /m32.2x10-5Oral, Diet
296alpha-Hexachlorocyclohexane (alpha-HCH)319-84-6Hepatic nodules and hepatocellular carcinomasLinearized multistage procedure, extra riskper µg /m31.8x10-3Oral, Diet
297beta-Hexachlorocyclohexane (beta-HCH)319-85-7Hepatic nodules and hepatocellular carcinomasLinearized multistage procedure, extra riskper µg /m35.3x10-4Oral, Diet
298delta-Hexachlorocyclohexane (delta-HCH)319-86-8Not Assessed under the IRIS program.
299epsilon-Hexachlorocyclohexane (epsilon-HC)6108-10-7Not Assessed under the IRIS program.
300gamma-Hexachlorocyclohexane (gamma-HCH)58-89-9Not Assessed under the IRIS program.
301technical Hexachlorocyclohexane (t-HCH)608-73-1Liver nodules and hepatocellular carcinomasLinearized multistage procedureper µg /m35.1x10-4Oral, Diet
302Hexachlorocyclopentadiene (HCCPD)77-47-4Not Assessed under the IRIS program.
303Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD57653-85-7Liver tumors (adenomas and carcinomas; neoplastic nodules and hepatocellular carcinomas)Linearized multistage procedure, extra riskper µg /m31.3Oral, Gavage
304Hexachloroethane67-72-1Information reviewed but value not estimated. Refer to IRIS Summary.
305Hexachlorophene70-30-4Not Assessed under the IRIS program.
306Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)121-82-4Not Assessed under the IRIS program.
3071,6-Hexamethylene diisocyanate822-06-0Not Assessed under the IRIS program.
308n-Hexane110-54-3Not Assessed under the IRIS program.
3092-Hexanone591-78-6Not Assessed under the IRIS program.
310Hexazinone51235-04-2Not Assessed under the IRIS program.
311Hydrazine/Hydrazine sulfate302-01-2Nasal cavity adenoma or adenocarcinomaLinearized multistage procedure, extra riskper µg /m34.9x10-3Inhalation
312Hydrogen Cyanide and Cyanide SaltsVariousNot Assessed under the IRIS program.
313Hydrogen chloride7647-01-0Not Assessed under the IRIS program.
314Hydrogen sulfide7783-06-4Not Assessed under the IRIS program.
315Hydroquinone123-31-9Not Assessed under the IRIS program.
316Imazalil35554-44-0Not Assessed under the IRIS program.
317Imazaquin81335-37-7Not Assessed under the IRIS program.
318Indeno[1,2,3-cd]pyrene193-39-5Not Assessed under the IRIS program.
319Iprodione36734-19-7Not Assessed under the IRIS program.
320Isobutyl alcohol78-83-1Not Assessed under the IRIS program.
321Isophorone78-59-1Not Assessed under the IRIS program.
322Isopropalin33820-53-0Not Assessed under the IRIS program.
323Isopropyl methyl phosphonic acid (IMPA)1832-54-8Not Assessed under the IRIS program.
324Isoxaben82558-50-7Not Assessed under the IRIS program.
325Lactofen77501-63-4Not Assessed under the IRIS program.
326Lead and compounds (inorganic)7439-92-1Not Assessed under the IRIS program.
327d-Limonene5989-27-5Not Assessed under the IRIS program.
328Linuron330-55-2Not Assessed under the IRIS program.
329Londax83055-99-6Not Assessed under the IRIS program.
330Malathion121-75-5Not Assessed under the IRIS program.
331Maleic anhydride108-31-6Not Assessed under the IRIS program.
332Maleic hydrazide123-33-1Not Assessed under the IRIS program.
333Maneb12427-38-2Not Assessed under the IRIS program.
334Manganese7439-96-5Not Assessed under the IRIS program.
335Mepiquat chloride24307-26-4Not Assessed under the IRIS program.
336Mercuric chloride (HgCl2)7487-94-7Not Assessed under the IRIS program.
337Mercury, elemental7439-97-6Not Assessed under the IRIS program.
338Merphos150-50-5Not Assessed under the IRIS program.
339Merphos oxide78-48-8Not Assessed under the IRIS program.
340Metalaxyl57837-19-1Not Assessed under the IRIS program.
341Methacrylonitrile126-98-7Not Assessed under the IRIS program.
342Methamidophos10265-92-6Not Assessed under the IRIS program.
343Methanol67-56-1Not Assessed under the IRIS program.
344Methidathion950-37-8Not Assessed under the IRIS program.
345Methomyl16752-77-5Not Assessed under the IRIS program.
346Methoxychlor72-43-5Not Assessed under the IRIS program.
3472-Methoxyethanol109-86-4Not Assessed under the IRIS program.
348Methyl acrylate96-33-3Not Assessed under the IRIS program.
349Methyl chloride74-87-3Not Assessed under the IRIS program.
350Methyl chlorocarbonate79-22-1Not Assessed under the IRIS program.
351Methyl ethyl ketone (MEK)78-93-3Not Assessed under the IRIS program.
352Methyl iodide74-88-4Not Assessed under the IRIS program.
353Methyl isobutyl ketone (MIBK)108-10-1Not Assessed under the IRIS program.
354Methyl isocyanate624-83-9Not Assessed under the IRIS program.
355Methyl methacrylate80-62-6Not Assessed under the IRIS program.
356Methyl parathion298-00-0Not Assessed under the IRIS program.
357Methyl tert-butyl ether (MTBE)1634-04-4Not Assessed under the IRIS program.
3584-(2-Methyl-4-chlorophenoxy) butyric acid (MCPB)94-81-5Not Assessed under the IRIS program.
3592-(2-Methyl-4-chlorophenoxy)propionic acid (MCPP)93-65-2Not Assessed under the IRIS program.
3602-Methyl-4-chlorophenoxyacetic acid (MCPA)94-74-6Not Assessed under the IRIS program.
361Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI)101-68-8Not Assessed under the IRIS program.
3624,4'-Methylene bis(N,N'-dimethyl)aniline101-61-1Not Assessed under the IRIS program.
363Methylmercury (MeHg)22967-92-6Not Assessed under the IRIS program.
3642-Methylnaphthalene91-57-6Not Assessed under the IRIS program.
3652-Methylphenol95-48-7Not Assessed under the IRIS program.
3664-Methylphenol106-44-5Not Assessed under the IRIS program.
3673-Methylphenol108-39-4Not Assessed under the IRIS program.
368Metolachlor51218-45-2Not Assessed under the IRIS program.
369Metribuzin21087-64-9Not Assessed under the IRIS program.
370Mirex2385-85-5Not Assessed under the IRIS program.
371Molinate2212-67-1Not Assessed under the IRIS program.
372Molybdenum7439-98-7Not Assessed under the IRIS program.
373Monochloramine10599-90-3Not Assessed under the IRIS program.
374Naled300-76-5Not Assessed under the IRIS program.
375Naphthalene91-20-3Information reviewed but value not estimated. Refer to IRIS Summary.
376Napropamide15299-99-7Not Assessed under the IRIS program.
377Nickel carbonyl13463-39-3Not Assessed under the IRIS program.
378Nickel refinery dustNALung cancerAdditive and multiplicativeper µg /m32.4x10-4Inhalation
379Nickel subsulfide12035-72-2Lung cancerAdditive and multiplicativeper µg /m34.8x10-4Inhalation
380Nickel, soluble saltsNANot Assessed under the IRIS program.
381Nitrapyrin1929-82-4Not Assessed under the IRIS program.
382Nitrate14797-55-8Not Assessed under the IRIS program.
383Nitric oxide10102-43-9Not Assessed under the IRIS program.
384Nitrite14797-65-0Not Assessed under the IRIS program.
385Nitrobenzene98-95-3Liver hepatocellular adenomas or carcinomas, kidney tubular adenomas or carcinomas, thyroid follicular cell adenomas or carcinomasMultistage model with linear extrapolation from the POD (LEC10).per µg /m34x10-5Inhalation
386Nitrogen dioxide10102-44-0Not Assessed under the IRIS program.
387Nitroguanidine556-88-7Not Assessed under the IRIS program.
388p-Nitrophenol100-02-7Not Assessed under the IRIS program.
3892-Nitropropane79-46-9Not Assessed under the IRIS program.
390N-Nitroso-N-methylethylamine10595-95-6Not Assessed under the IRIS program.
391N-Nitroso-di-n-butylamine924-16-3Bladder and esophagus tumorsLinearized multistage procedure, extra riskper µg /m31.6x10-3Oral, Drinking water
392N-Nitrosodi-N-propylamine621-64-7Not Assessed under the IRIS program.
393N-Nitrosodiethanolamine1116-54-7Not Assessed under the IRIS program.
394N-Nitrosodiethylamine55-18-5Liver tumorsWeibull, extra riskper µg /m34.3x10-2Oral, Drinking water
395N-Nitrosodimethylamine62-75-9Liver tumorsWeibull, extra riskper µg /m31.4x10-2Oral, Drinking water
396N-Nitrosodiphenylamine86-30-6Not Assessed under the IRIS program.
397N-Nitrosopyrrolidine930-55-2Hepatocellular carcinoma and adenomaLinearized multistage procedure, extra riskper µg /m36.1x10-4Oral, Diet
398Nonabromodiphenyl ether63936-56-1Not Assessed under the IRIS program.
399Norflurazon27314-13-2Not Assessed under the IRIS program.
400NuStar85509-19-9Not Assessed under the IRIS program.
401Octabromodiphenyl ether32536-52-0Not Assessed under the IRIS program.
402Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)2691-41-0Not Assessed under the IRIS program.
403Oryzalin19044-88-3Not Assessed under the IRIS program.
404Oxadiazon19666-30-9Not Assessed under the IRIS program.
405Oxamyl23135-22-0Not Assessed under the IRIS program.
406Oxyfluorfen42874-03-3Not Assessed under the IRIS program.
407Paclobutrazol76738-62-0Not Assessed under the IRIS program.
408Paraquat1910-42-5Not Assessed under the IRIS program.
409Parathion56-38-2Not Assessed under the IRIS program.
410Pendimethalin40487-42-1Not Assessed under the IRIS program.
411Pentabromodiphenyl ether32534-81-9Not Assessed under the IRIS program.
4122,2',4,4',5-Pentabromodiphenyl ether (BDE-99)60348-60-9Not Assessed under the IRIS program.
413Pentachlorobenzene608-93-5Not Assessed under the IRIS program.
414Pentachlorocyclopentadiene25329-35-5Not Assessed under the IRIS program.
415Pentachloronitrobenzene (PCNB)82-68-8Not Assessed under the IRIS program.
416Pentachlorophenol87-86-5Not Assessed under the IRIS program.
417Pentafluoroethane354-33-6Not Assessed under the IRIS program.
418Perchlorate (ClO4) and Perchlorate Salts7790-98-9Not Assessed under the IRIS program.
419Permethrin52645-53-1Not Assessed under the IRIS program.
420Phenanthrene85-01-8Not Assessed under the IRIS program.
421Phenmedipham13684-63-4Not Assessed under the IRIS program.
422Phenol108-95-2Not Assessed under the IRIS program.
423m-Phenylenediamine108-45-2Not Assessed under the IRIS program.
424Phenylmercuric acetate62-38-4Not Assessed under the IRIS program.
425Phosalone2310-17-0Not Assessed under the IRIS program.
426Phosgene75-44-5Not Assessed under the IRIS program.
427Phosmet732-11-6Not Assessed under the IRIS program.
428Phosphine7803-51-2Not Assessed under the IRIS program.
429Phosphoric acid7664-38-2Not Assessed under the IRIS program.
430Phthalic anhydride85-44-9Not Assessed under the IRIS program.
431Picloram1918-02-1Not Assessed under the IRIS program.
432Pirimiphos-methyl29232-93-7Not Assessed under the IRIS program.
433Polychlorinated biphenyls (PCBs)1336-36-3Liver hepatocellular adenomas, carcinomas, cholangiomas, or cholangiocarcinomasLinear extrapolation below LED10sper µg /m31x10-4Oral, Diet
434Potassium cyanide151-50-8Not Assessed under the IRIS program.
435Potassium silver cyanide506-61-6Not Assessed under the IRIS program.
436Prochloraz67747-09-5Not Assessed under the IRIS program.
437Prometon1610-18-0Not Assessed under the IRIS program.
438Prometryn7287-19-6Not Assessed under the IRIS program.
439Pronamide23950-58-5Not Assessed under the IRIS program.
440Propachlor1918-16-7Not Assessed under the IRIS program.
441Propanil709-98-8Not Assessed under the IRIS program.
442Propargite2312-35-8Not Assessed under the IRIS program.
443Propargyl alcohol107-19-7Not Assessed under the IRIS program.
444Propazine139-40-2Not Assessed under the IRIS program.
445Propham122-42-9Not Assessed under the IRIS program.
446Propiconazole60207-90-1Not Assessed under the IRIS program.
447beta-Propiolactone57-57-8Not Assessed under the IRIS program.
448Propionaldehyde123-38-6Not Assessed under the IRIS program.
449Propylene glycol57-55-6Not Assessed under the IRIS program.
450Propylene glycol monoethyl ether52125-53-8Not Assessed under the IRIS program.
451Propylene glycol monomethyl ether (PGME)107-98-2Not Assessed under the IRIS program.
452Propylene oxide75-56-9Nasal cavity hemangioma or hemangiosarcomaLinearized multistage procedure, extra riskper µg /m33.7x10-6Inhalation
453Propyleneimine75-55-8Not Assessed under the IRIS program.
454Pursuit81335-77-5Not Assessed under the IRIS program.
455Pydrin51630-58-1Not Assessed under the IRIS program.
456Pyrene129-00-0Not Assessed under the IRIS program.
457Pyridine110-86-1Not Assessed under the IRIS program.
458Quinalphos13593-03-8Not Assessed under the IRIS program.
459Quinoline91-22-5Information reviewed but value not estimated. Refer to IRIS Summary.
460Quinone106-51-4Not Assessed under the IRIS program.
461Radium 226,2287440-14-4Not Assessed under the IRIS program.
462Radon 22214859-67-7Not Assessed under the IRIS program.
463Refractory ceramic fibersNAInformation reviewed but value not estimated. Refer to IRIS Summary.
464Resmethrin10453-86-8Not Assessed under the IRIS program.
465Rotenone83-79-4Not Assessed under the IRIS program.
466Savey78587-05-0Not Assessed under the IRIS program.
467Selenious acid7783-00-8Not Assessed under the IRIS program.
468Selenium and Compounds7782-49-2Not Assessed under the IRIS program.
469Selenium sulfide7446-34-6Not Assessed under the IRIS program.
470Selenourea630-10-4Not Assessed under the IRIS program.
471Sethoxydim74051-80-2Not Assessed under the IRIS program.
472Silver7440-22-4Not Assessed under the IRIS program.
473Silver cyanide506-64-9Not Assessed under the IRIS program.
474Simazine122-34-9Not Assessed under the IRIS program.
475Sodium azide26628-22-8Not Assessed under the IRIS program.
476Sodium cyanide143-33-9Not Assessed under the IRIS program.
477Sodium diethyldithiocarbamate148-18-5Not Assessed under the IRIS program.
478Sodium fluoroacetate62-74-8Not Assessed under the IRIS program.
479Strontium7440-24-6Not Assessed under the IRIS program.
480Strychnine57-24-9Not Assessed under the IRIS program.
481Styrene100-42-5Not Assessed under the IRIS program.
482Systhane88671-89-0Not Assessed under the IRIS program.
483Tebuthiuron34014-18-1Not Assessed under the IRIS program.
484Terbacil5902-51-2Not Assessed under the IRIS program.
485Terbutryn886-50-0Not Assessed under the IRIS program.
486Tetrabromodiphenyl ether40088-47-9Not Assessed under the IRIS program.
4872,2',4,4'-Tetrabromodiphenyl ether (BDE-47)5436-43-1Not Assessed under the IRIS program.
4881,2,4,5-Tetrachlorobenzene95-94-3Not Assessed under the IRIS program.
489Tetrachlorocyclopentadiene695-77-2Not Assessed under the IRIS program.
4901,1,1,2-Tetrachloroethane630-20-6Hepatocellular adenoma or carcinomaLinearized multistage procedure, extra riskper µg /m37.4x10-6Oral, Gavage
4911,1,2,2-Tetrachloroethane79-34-5Information reviewed but value not estimated. Refer to IRIS Summary.
492Tetrachloroethylene127-18-4Not Assessed under the IRIS program.
4932,3,4,6-Tetrachlorophenol58-90-2Not Assessed under the IRIS program.
494Tetrachlorovinphos961-11-5Not Assessed under the IRIS program.
495Tetraethyl lead78-00-2Not Assessed under the IRIS program.
496Tetraethyldithiopyrophosphate3689-24-5Not Assessed under the IRIS program.
4971,1,1,2-Tetrafluoroethane811-97-2Not Assessed under the IRIS program.
498Thallium (I), soluble saltsVariousNot Assessed under the IRIS program.
499Thallium acetate563-68-8Not Assessed under the IRIS program.
500Thallium carbonate6533-73-9Not Assessed under the IRIS program.
501Thallium chloride7791-12-0Not Assessed under the IRIS program.
502Thallium nitrate10102-45-1Not Assessed under the IRIS program.
503Thallium oxide1314-32-5Not Assessed under the IRIS program.
504Thallium selenite12039-52-0Not Assessed under the IRIS program.
505Thallium(I) sulfate7446-18-6Not Assessed under the IRIS program.
506Thiobencarb28249-77-6Not Assessed under the IRIS program.
507Thiophanate-methyl23564-05-8Not Assessed under the IRIS program.
508Thiram137-26-8Not Assessed under the IRIS program.
509Toluene108-88-3Not Assessed under the IRIS program.
5102,4-/2,6-Toluene diisocyanate mixture (TDI)26471-62-5Not Assessed under the IRIS program.
511Toxaphene8001-35-2Hepatocellular carcinomas and neoplastic nodulesLinearized multistage procedure, extra riskper µg /m33.2x10-4Oral, Diet
512Tralomethrin66841-25-6Not Assessed under the IRIS program.
513Triallate2303-17-5Not Assessed under the IRIS program.
514Triasulfuron82097-50-5Not Assessed under the IRIS program.
5151,2,4-Tribromobenzene615-54-3Not Assessed under the IRIS program.
516Tribromochloromethane594-15-0Not Assessed under the IRIS program.
517Tribromodiphenyl ether49690-94-0Not Assessed under the IRIS program.
518Tributyltin oxide (TBTO)56-35-9Not Assessed under the IRIS program.
5191,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)76-13-1Not Assessed under the IRIS program.
520Trichloroacetic acid76-03-9Information reviewed but value not estimated. Refer to IRIS Summary.
5211,2,4-Trichlorobenzene120-82-1Not Assessed under the IRIS program.
522Trichlorocyclopentadiene77323-84-3Not Assessed under the IRIS program.
5231,1,2-Trichloroethane79-00-5Hepatocellular carcinomaLinearized multistage procedure, extra riskper µg /m31.6x10-5Oral, Gavage
5241,1,1-Trichloroethane71-55-6Information reviewed but value not estimated. Refer to IRIS Summary.
525Trichloroethylene79-01-6Renal cell carcinoma, non-Hodgkin's lymphoma, and liver tumorsLow-dose linear extrapolation from the point of departure (LEC01) with a factor of 4 applied to include non-Hodgkin's lymphoma (NHL) and liver cancer risks, combined riskper µg /m34.1x10-6Inhalation
526Trichlorofluoromethane75-69-4Not Assessed under the IRIS program.
5272,4,5-Trichlorophenol95-95-4Not Assessed under the IRIS program.
5282,4,6-Trichlorophenol88-06-2LeukemiaLinearized multistage procedure, extra riskper µg /m33.1x10-6Oral,Diet
5292(2,4,5-Trichlorophenoxy) propionic acid (2,4,5-TP)93-72-1Not Assessed under the IRIS program.
5302,4,5-Trichlorophenoxyacetic acid (2,4,5-T)93-76-5Not Assessed under the IRIS program.
5311,1,2-Trichloropropane598-77-6Not Assessed under the IRIS program.
5321,2,3-Trichloropropane96-18-4Not Assessed under the IRIS program.
533Tricresol1319-77-3Not Assessed under the IRIS program.
534Tridiphane58138-08-2Not Assessed under the IRIS program.
535Triethylamine121-44-8Not Assessed under the IRIS program.
536Triethylene glycol monobutyl ether143-22-6Not Assessed under the IRIS program.
537Triethylene glycol monoethyl ether112-50-5Not Assessed under the IRIS program.
538Trifluralin1582-09-8Not Assessed under the IRIS program.
5392,2,4-Trimethylpentane540-84-1Not Assessed under the IRIS program.
5401,3,5-Trinitrobenzene99-35-4Not Assessed under the IRIS program.
5412,4,6-Trinitrotoluene (TNT)118-96-7Not Assessed under the IRIS program.
542Uranium, natural7440-61-1Not Assessed under the IRIS program.
543Uranium, soluble saltsNANot Assessed under the IRIS program.
544Urea57-13-6Not Assessed under the IRIS program.
545Vanadium pentoxide1314-62-1Not Assessed under the IRIS program.
546Vernam1929-77-7Not Assessed under the IRIS program.
547Vinclozolin50471-44-8Not Assessed under the IRIS program.
548Vinyl acetate108-05-4Not Assessed under the IRIS program.
549Vinyl bromide593-60-2Not Assessed under the IRIS program.
550Vinyl chloride75-01-4Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodulesLMS methodper µg /m34.4x10-6Inhalation
551Vinyl chloride75-01-4Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodulesLED 10/ linear methodper µg /m34.4x10-6Inhalation
552Vinyl chloride75-01-4Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodulesLMS methodper µg /m38.8x10-6Inhalation
553Vinyl chloride75-01-4Liver angiosarcomas, angiomas, hepatomas, and neoplastic nodulesLED 10/ linear methodper µg /m38.8x10-6Inhalation
554Warfarin81-81-2Not Assessed under the IRIS program.
555White phosphorus7723-14-0Not Assessed under the IRIS program.
556Xylenes1330-20-7Not Assessed under the IRIS program.
557Zinc and Compounds7440-66-6Not Assessed under the IRIS program.
558Zinc cyanide557-21-1Not Assessed under the IRIS program.
559Zinc phosphide1314-84-7Not Assessed under the IRIS program.
560Zineb12122-67-7Not Assessed under the IRIS program.

Rationale

See also

References


Related files

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